Resveratrol, one of the compounds found in grape (and red wine), would protect against lung cancer when administered nasally.
Present in grapes, red wine, blackberries and blueberries, resveratrol is known for its anti-aging properties but also for its preventive action against cancers affecting the digestive tract. A new study from the University of Geneva, looked at the effects of the molecule on lung cancer. Thanks to a new mode of nasal administration, the team of Genevan researchers has indeed obtained very promising results in mice.
For this study published in the journal Nature, four groups of mice were formed. The first (the control group) received no carcinogen from cigarette smoke and no resveratrol treatment. The second received only the carcinogen, the third carcinogen as well as the treatment, and the fourth received only the treatment. “In the mice that received a carcinogen, those who took resveratrol developed fewer and smaller tumors than the untreated mice,” explains Prof. Muriel Cuendet from the UNIGE Faculty of Science. And if we compare the two groups that were not exposed to the carcinogen, we found that 63% of the mice that had received treatment did not develop cancer, compared to only 12.5% of the untreated mice. “Resveratrol would therefore play a preventive role against lung cancer,” says the researcher.
The researchers’ challenge was to find a formulation to administer resveratrol nasally because the molecule, when ingested, is metabolized and eliminated within minutes, and therefore does not have time to reach the lungs . “This formulation, applicable in humans, allows the compound to reach the lungs,” says Aymeric Monteillier, a researcher at UNIGE.